Signal Recognition Particle (SRP) in complex with receptor (SR) at 3.9 Angstrom
Science, 331, 881-886 (2011)
Still an unreleased structure in the Protein Data Bank but will be coming out soon.
The Signal Recognition Particle is an RNA-protein complex which delivers at the time of translation (co-translationally) membrane and secretory proteins. The SRP is made of a surprisingly long double stranded RNA, I wonder if it stays "straight" thanks to the aid of the protein, and why would it want to do that?
A. Robbins-Pianka and M. D. Rice and M. P. Weir @ Wesleyan, Connecticut
Translation initiation sites (TIS) are influenced by secondary structure downstream and upstream of this sites in highly expressed genes.
Bioinformatics, 26, 2651-2655 (2011)
The results are clearly explained in their abstract:
"Trends in base composition and base-pairing probabilities suggest that efficient translation initiation and high protein expression are aided by reduced secondary structure upstream and downstream of the TIS. However, the downstream reduction is not observed for sets of TISs with nucleotide sequence contexts unfavorable for translation initiation, consistent with previous suggestions that secondary structure downstream of the ribosome can facilitate TIS recognition."
And in the following figure:
0 comments:
Post a Comment