Friday, November 12, 2010

Locked nucleic acids (LNA) can be interpreted via rigid blocks too

A new crystal structure (NAR, 2010, 38, 6729) shows a representation of locked nucleic acids using the rigid-body parameter formalism imbeded in 3DNA. It's interesting to see that stretching this type of data in an orderly study one could even get to compute global properties of LNA's ala PNAS 98 paper of Olson, Gorin, et al.
It's also fun to redo their images into a prettier picture accompanied by numbers and compare the numbers to what happens with RNA conformations, and also with DNA conformations. The other way I've seen to modulate helical stretches of nucleic acids is with aptamers like the one of a previous post.