Tuesday, November 3, 2009

Again RNA gets the Nobel Prize!

For a beginner it takes time to put into perspective the history of scientific interest in RNA.

Here are some landmarks on RNA Structure:

-- 1956 Alex Rich and David Davies -- Double Stranded RNA **JACS
-- 1956 Mahlon Hoagland and Paul Zamecnik -- tRNA (then called sRNA - soluble RNA) **J. Biol. Chem.
-- 1965 Robert W. Holley -- yeast tRNAala sequenced and secondary structure proposed. **SCIENCE
-- 1968 Nobel Medicine -- Robert W. Holley, Har Gobind Khorana, Marshall W. Nirenberg
-- 1974 Rich's (**Science) and Klug's (**Nature) Groups yeast tRNAphe x-ray structure at 3.0 Angstrom.
-- 1989 Nobel Chemistry -- Sidney Altman and Tom Cech -- Ribozymes
-- 1994 Pley, McKay -- Hammerhead RNA
-- 1996 J. Cate et al. -- P4-P6 Group I Intron.
-- 2000 Various groups publish rRNA x-ray structure.
-- 2006 Nobel Medicine -- Craig Mello and Andrew Fire -- RNAi
-- 2006 Nobel Chemistry -- Roger Kornberg -- RNAPol
-- 2008 Pyle et al. -- Group II Intron.
-- 2009 Nobel Chemistry -- Venkatraman Ramakrishnan, Thomas A. Steitz, Ada E. Yonath -- rRNA