Friday, June 5, 2009

Ribozyme Ligase

According to Michael P. Robertson and William P. Scott from U.C. Santa Cruz as published in SCIENCE (2007), 315, 1549 - 1553.

Life originated, according to the RNA World hypothesis, from self-replicating ribozymes that catalyzed ligation of RNA fragments. We have solved the 2.6 angstrom crystal structure of a ligase ribozyme that catalyzes regiospecific formation of a 5` to 3` phosphodiester bond between the 5`-triphosphate and the 3`-hydroxyl termini of two RNA fragments.