Saturday, September 3, 2005

Moore and Steitz, Tr. in Bioch. Sci. June 2005

There is still no atomic-resolution structure for a 70S ribosome in any of its states. Consequently, we have no idea why the peptydil-transferase activity of the 70S ribosome is ~10^4 times that of its isolated 50S subunit.

Friday, September 2, 2005

Onoa and Tinoco, Curr. Op. Str. Bio. 2003

The ultimate application of a better understanding of RNA folding is to predict the folded, partially folded and unfolded states of any RNA in physiological environment.

Thursday, September 1, 2005

Chen and Dill, PNAS, 2002

The principle that emerges, for which there is growing experimental support, is that although protein folding tends to involve highly cooperative two-state thermodynamic transitions, without detectable intermediates, the folding of RNA secondary structures may involve rugged landscapes, often with more complex intermediate states.