Saturday, September 3, 2005
There is still no atomic-resolution structure for a 70S ribosome in any of its states. Consequently, we have no idea why the peptydil-transferase activity of the 70S ribosome is ~10^4 times that of its isolated 50S subunit.
Posted by esguerroto at 9:43 PM
Friday, September 2, 2005
Thursday, September 1, 2005
The principle that emerges, for which there is growing experimental support, is that although protein folding tends to involve highly cooperative two-state thermodynamic transitions, without detectable intermediates, the folding of RNA secondary structures may involve rugged landscapes, often with more complex intermediate states.
Posted by esguerroto at 9:38 PM